Many people hope to reverse the process of ageing in a bid to remain healthier and live longer. And now researchers have made a breakthrough!
As the body ages, it loses its ability to control how genes are regulated and they gradually become more damaged until we ultimately die. A gene is activated by signals from inside or outside the cell to make a molecular message known as RNA.
The decision on which type of ‘message’ is created by a group of around 300 proteins is known as “splicing factors”. However, as we get older the amount of splicing factors the proteins are able to make steadily decreases. Older cells are then ultimately less able to turn genes on and off to react to the environment which makes us more vulnerable to diseases which kill us off.
However, researchers at University of Exeter, UK, have found a way to turn splicing factors back on by treating old cells with a chemical that releases small amounts of hydrogen sulphide. They were able to increase levels of some splicing factors, and to rejuvenate old human cells.
Hydrogen sulphide is a molecule that is found naturally in our bodies and has been shown to improve several features of age-related disease in animals. But it can be toxic in large amounts, so Lorna Harries, Associate Professor in Molecular Genetics and Matt Whiteman, Professor of Experimental Therapeutics, needed to find a way to deliver it directly to the part of the cell where it is needed.
“By using a ‘molecular postcode’ we have been able to deliver the molecule directly to the mitochondria, the structures that produce energy in cells, where we think it acts, allowing us to use tiny doses, which are less likely to cause side effects,” scientists claim. The ageing process in cells have successfully been reversed for the first time in a move which could help beat the signs of Alzheimer’s and dementia.
C/o: Sean Martin, published Aug 14, 2018